Biopharmaceutical Process Optimization with Simulation and Scheduling Tools
نویسندگان
چکیده
منابع مشابه
Biopharmaceutical Process Optimization with Simulation and Scheduling Tools.
Design and assessment activities associated with a biopharmaceutical process are performed at different levels of detail, based on the stage of development that the product is in. Preliminary "back-of-the envelope" assessments are performed early in the development lifecycle, whereas detailed design and evaluation are performed prior to the construction of a new facility. Both the preliminary a...
متن کاملOptimization of Biopharmaceutical Manufacturing with Scheduling Tools - Experiences from the Real World
This paper presents industrial experience with a resource-constrained batch process scheduling program. The batch process representation is loosely based on the ISA S88 batch process standard. This representation allows the import of batch process information from other software, e.g. batch process simulators. The scheduling algorithm is a non-optimization approach that proceeds in two steps. F...
متن کاملFluorescence-based tools to improve biopharmaceutical process development
Background Process optimization and control are essential to match biopharmaceutical market demands. Early-steps in the development of new processes require screening hundreds of transfected clones in order to select those with the best expression characteristics, and identifying optimal environmental conditions for these clones to grow and express the protein of interest. While some culture sy...
متن کاملSimulation Optimization for Process Scheduling through Simulated Annealing
This paper presents a simulation optimization of a real scheduling problem in industry, simulated annealing is introduced for this purpose. Investigation is performed into the practicality of using simulated annealing to produce high quality schedules. Results on the solution quality and computational effort show the inherent properties of the simulated annealing. It is shown that when using th...
متن کاملEvaluation and Ranking of Discrete Simulation Tools
In studying through simulation, choosing an appropriate tool/language would be a difficult task because many of them are available. On the other hand, few research works focus on evaluation of simulation tools/languages and their comparison. This paper makes a couple of evaluations and ranks more than fifty simulation tools that are currently available. The first evaluation and ranking is in th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioengineering
سال: 2014
ISSN: 2306-5354
DOI: 10.3390/bioengineering1040154